L-甲状腺素钠-苏州东南药业股份有限公司

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Chinese Name 中文名	L-甲状腺素钠
English Name 英文名	Levothyroxine Sodium
Alias 别名	3,5,3’,5’-tetraiodothyronine;beta-[(3,5-diiodo-4-hydroxyphenoxy)-3,5-diiodophenyl]alanine;l-3,5,3’,5’-tetraiodothyronine;l-t4;o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-l-tyrosin;o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine;t4(hormone);tetraiodothyronine
CAS NO.	25416-65-3
Formula 分子式	C15H10I4NO4
M.W. 分子量	798.85
Class 分类	原料药

L-Thyroxine is a synthetic form of thyroxine and a hormone replacement drug. L-Thyroxine is typically used to treat hypothyroidism. L-Thyroxine may also be used to treat goiter via its ability to lower thyroid-stimulating hormone (TSH), a hormone that is considered goiter-inducing.由两个3，5-二碘酪氨酸分子偶联而成的一种碘化的酪氨酸衍生物，是甲状腺的主要激素。主要控制耗氧速率和总代谢速率。具有促进一般组织代谢，提高神经兴奋性和身体发育作用。用以治疗甲状腺机能减退，粘液性水肿和克汀病等。左甲状腺素钠（L-T4)作用迟缓而持久，起效较慢，病人易耐受。1次/d，服用方便，且剂量易于掌握。左甲状腺素钠（L-T4)在外周组织脱碘，产生足量的碘塞罗宁(T3)满足生理需要，是治疗甲减的理想制剂，现已成为治疗甲减的首选药物。而且左甲状腺素钠（L-T4)的半衰期长达7天，吸收相对缓慢，即使漏服1天也无多大影响，可以于漏服的次日加服1天的剂量。该药物常见的商品名包括：欧洲的：Thyrax, Euthyrox（中文名：优甲乐）, Levaxin, L-thyroxine, Eltroxin 和 Thyrax Duotab；北美的：Thyrox in South Asia; Eutirox, Tirosint,Levoxyl and Synthroid；中国大陆的：“泽宁”“尤仙”等。同时，还有一些无商品名产品。

化学数据

溶解性 (25°C)

•DMSO 155 mg/mL

•水 <1 mg/mL

•乙醇 <1 mg/mL

稳定性 2年 -20°C粉状

2周4°C溶于DMSO

6月-80°C溶于DMSO

【熔点】

207 °C

【比旋光度】

16 º (c=2,1M HCl/alcohol 1/4)

【储存条件】

Store at 0-5°C

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2. Svensson J, Ericsson UB, Nilsson P, et al.. Levothyroxine treatment reduces thyroid size in children and adolescents with chronic autoimmune thyroiditis. The Journal of clinical endocrinology and metabolism. 2006.May, 91 (5): 1729–34. doi:10.1210/jc.2005-2400.PMID 16507633.
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7. Ruth H. Michel, Patricia J. Neafsey, Laura Cox Dzurec: Self Medication Practices among Patients taking Levothyroxine. The Internet Journal of Advanced Nursing Practice. 2004. Volume 6 Number 2
8. Lilja JJ, Laitinen K, Neuvonen PJ. Effects of grapefruit juice on the absorption of levothyroxine. Br J Clin Pharmacol. 2005.September, 60 (3): 337–41. doi:10.1111/j.1365-2125.2005.02433.x. PMC 1884777. PMID 16120075.
9. Benvenga, Salvatore; Bartolone, L.; Pappalardo, M.A.; Russo, A.; Lapa, D.; Giorgianni, G.; Saraceno, G.; Trimarchi, F. Altered Intestinal Absorption of L-Thyroxine Caused by Coffee. Thyroid (New York: Mary Ann Liebert, Inc.). March 2008, 18 (3): 293–301 [2009-05-16].doi:10.1089/thy.2007.0222. PMID 18341376

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